Global DNA Demethylation During Mouse Erythropoiesis in Vivo

• DOI: 10.1126/science.1207306
• Publication Date: 2011-11-10T19:44:28Z
• Authors: Jeffrey R. Shears...; Ramona Pop; Christoph Bock; Patrick Boyle; Alexander Meissner; Merav Socolovsky
• Keywords: DNA Replication; 0301 basic medicine; 570; Genome; Erythroblasts; Transcription, Genetic; Gene Expression Regulation, Developmental; Sequence Analysis, DNA; beta-Globins; DNA Methylation; Embryo, Mammalian; Locus Control Region; S Phase; Mice; 03 medical and health sciences; Long Interspersed Nucleotide Elements; Gene Expression Regulation; Liver; Animals; Developmental; CpG Islands; Erythropoiesis; Dinucleoside Phosphates

Erythroblasts undergoing differentiation into red cells lose one-third of DNA methylation marks at nearly all genomic loci.