Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

• DOI: 10.1126/science.1209200
• Publication Date: 2011-10-21T03:52:40Z
• Authors: Daniel K. Nomura; Bradley E. Morrison; Jacqueline L. Bla...; Jonathan Z. Long; Steven G. Kinsey; Maria Cecilia G. ...; Anna M. Ward; Yun Kyung Hahn; Aron H. Lichtman; Bruno Conti; Benjamin F. Cravatt
• Keywords: Inflammation; Lipopolysaccharides; 0303 health sciences; Arachidonic Acid; Hydrolysis; Brain; Arachidonic Acids; Glycerides; Mice; 03 medical and health sciences; Liver; Cannabinoid Receptor Modulators; Cyclooxygenase 1; Animals; Cytokines; Eicosanoids; Metabolomics; Benzodioxoles; Enzyme Inhibitors; Inflammation Mediators; Lung; Endocannabinoids

A new tissue-specific pathway for the synthesis of proinflammatory prostaglandins is described.