TERT promoter mutations and telomerase reactivation in urothelial cancer

• DOI: 10.1126/science.1260200
• Publication Date: 2015-02-06T05:02:08Z
• Authors: Sumit Borah; Linghe Xi; Arthur J. Zaug; Natasha M. Powell; Garrett M. Dancik; Scott B. Cohen; James C. Costello; Dan Theodorescu; Thomas R. Cech
• Keywords: Urothelial cancer; Telomerase RNA component

The downstream effects of false promotion Special DNA sequences at the ends chromosomes, called telomeres, are replenished by a dedicated enzyme telomerase. A subset human tumors harbors mutations in promoter region TERT gene, which codes for subunit Borah et al. explored cells derived from urothelial (urinary tract) cancers. were associated with aberrantly high levels mRNA, protein and telomerase activity, longer telomeres. small study clinical samples suggested that mRNA may be marker more aggressive Science , this issue p. 1006