Analgesia Mediated by a Direct Spinal Action of Narcotics

• DOI: 10.1126/science.1273597
• Publication Date: 2006-10-05T15:51:28Z
• Authors: Tony L. Yaksh; Thomas A. Rudy
• Keywords: Subarachnoid space; Narcotic

Narcotic analgetics administered directly into the spinal subarachnoid space of rat via a chronically inserted catheter produce potent analgesia that can be antagonized by naloxone. The narcotics, acting only at level, changed cord function to block not reflexes but also operant response painful stimuli.