Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

• DOI: 10.1126/science.1702903
• Publication Date: 2006-10-05T22:10:16Z
• Authors: Yuji Yamanashi; Terutaka Kakiuchi; Junichiro Mizuguchi; Tadashi Yamamoto; Kumao Toyoshima
• Keywords: LYN; Tyrosine-protein kinase CSK

Antigen is thought to cross-link membrane-bound immunoglobulins (Igs) of B cells, causing proliferation and differentiation or the inhibition growth. Protein tyrosine kinases are probably involved in signal transduction for cell differentiation. The Src-like protein kinase Lyn expressed preferentially cells. its activity could be coimmunoprecipitated with IgM from detergent lysates. Cross-linking induced a rapid increase phosphorylation at least ten distinct proteins Thus, physically associated IgM, suggested participate antigen-mediated transduction.