Intrathecal Capsaicin Depletes Substance P in the Rat Spinal Cord and Produces Prolonged Thermal Analgesia

• DOI: 10.1126/science.228392
• Publication Date: 2006-10-05T16:39:42Z
• Authors: Tony L. Yaksh; David H. Farb; Susan E. Leeman; Thomas M. Jessell
• Keywords: Capsaicin; Intrathecal

A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal chemical pain thresholds rat but no apparent change responses to noxious mechanical stimuli.