Essential Ca 2+ -Binding Motif for Ca 2+ -Sensitive Inactivation of L-Type Ca 2+ Channels

• DOI: 10.1126/science.270.5241.1502
• Publication Date: 2006-10-27T18:19:42Z
• Authors: Marita de Leon; Yan Wang; Lisa Jones; Edward Perez-Reyes; Xiangyang Wei; Tuck Wah Soong; Terry P. Snutch; David T. Yue
• Keywords: EF hand

Intracellular calcium (Ca2+) inhibits the opening of L-type (alpha 1C) Ca2+ channels, providing physiological control entry into a wide variety cells. A structural determinant this Ca(2+)-sensitive inactivation was revealed by chimeric channels derived from parental alpha 1C and 1E latter which is neuronal channel lacking inactivation. consensus Ca(2+)-binding motif (an EF hand), located on subunit, required for Donation EF-hand region to conferred Ca(2+)-inactivating phenotype. These results strongly suggest that binding subunit initiates