Role of NK1.1 + T Cells in a T H 2 Response and in Immunoglobulin E Production

• DOI: 10.1126/science.270.5243.1845
• Publication Date: 2006-10-27T18:19:42Z
• Authors: Tomohiro Yoshimoto; Albert Bendelac; Cynthia Watson; Jane Hu-Li; William E. Paul
• Keywords: CD4-Positive T-Lymphocytes; 0301 basic medicine; Mice, Inbred BALB C; Thymus Gland; Immunoglobulin E; 3. Good health; Killer Cells, Natural; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Th2 Cells; Animals; Interleukin-4; Cells, Cultured; Spleen

Immune responses dominated by interleukin-4 (IL-4)-producing T helper type 2 (TH2) cells or interferon gamma (IFN-gamma)-producing 1 (TH1) express distinctive protection against infection with different pathogens. Interleukin-4 promotes the differentiation of naïve CD4+ into IL-4 producers and suppresses their development IFN-gamma producers. CD1-specific splenic CD4+NK1.1+ cells, a numerically minor population, produced promptly on in vivo stimulation. This cell population was essential for induction IL-4-producing switching to immunoglobulin E, an IL-4-dependent event, response injection antibodies D.