Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

• DOI: 10.1126/science.271.5251.994
• Publication Date: 2006-10-27T18:30:41Z
• Authors: Streamson C. Chua; Wendy K. Chung; X. Sharon Wu-Peng; Yiying Zhang; Shun-Mei Liu; Louis Tartaglia; Rudolph L. Leibel
• Keywords: Leptin receptor; Cloning (programming)

Mice harboring mutations in the obese ( ob ) and diabetes db genes display similar phenotypes, it has been proposed that these encode ligand receptor, respectively, for a physiologic pathway regulates body weight. The cloning of , demonstration encodes secreted protein (leptin) binds specifically to receptor (OB-R) brain, have validated critical aspects this hypothesis. Here is shown by genetic mapping genomic analysis mouse rat fatty (a homolog ), gene encoding OB-R are same gene.