Distance-Dependent Electron Transfer in DNA Hairpins

• DOI: 10.1126/science.277.5326.673
• Publication Date: 2002-07-27T09:44:47Z
• Authors: Frederick D. Lewis; Taifeng Wu; Yifan Zhang; Robert L. Letsinger; Scott R. Greenfield; Michael R. Wasiel...
• Keywords: Duplex (building); Photoinduced electron transfer; Deoxyguanosine

The distance dependence of photoinduced electron transfer in duplex DNA was determined for a family synthetic hairpins which stilbene dicarboxamide forms bridge connecting two oligonucleotide arms. Investigation the fluorescence and transient absorption spectra these established that no occurs hairpin has six deoxyadenosine-deoxythymidine base pairs. However, introduction single deoxyguanosine-deoxycytidine pair resulted distance-dependent quenching formation anion radical. Kinetic analysis suggests is somewhat more effective than proteins as medium but it does not function molecular wire.