Sustained Delivery of Proteins for Novel Therapeutic Products

• DOI: 10.1126/science.281.5380.1161
• Publication Date: 2002-07-27T09:43:20Z
• Authors: Raymond T. Bartus; Mark A. Tracy; Dwaine F. Emerich; Stephen E. Zale
• Keywords: Clinical Trials as Topic; Drug Carriers; 0303 health sciences; Human Growth Hormone; Temperature; Proteins; Microspheres; 3. Good health; 03 medical and health sciences; Drug Delivery Systems; Freeze Drying; Drug Stability; Delayed-Action Preparations; Humans; Particle Size; Polyglactin 910

R ecent developments in biotechnology have resulted a number of powerful new protein therapies for many heretofore untreatable conditions, including hepatitis C, multiple sclerosis, hormonal disorders, and different cancers. In spite this, the use most drugs is limited by