Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons

• DOI: 10.1126/science.286.5448.2358
• Publication Date: 2002-07-27T09:42:47Z
• Authors: Antonella Riccio; Sohyun Ahn; Christopher M. Da...; Julie A. Blendy; David D. Ginty
• Keywords: Mediator

Nerve growth factor (NGF) and other neurotrophins support survival of neurons through processes that are incompletely understood. The transcription CREB is a critical mediator NGF-dependent gene expression, but whether family factors regulate expression genes contribute to sympathetic unknown. CREB-mediated was both necessary for sufficient on its own promote neurons. Moreover, Bcl-2 activated by NGF CREB-dependent transcriptional mechanism. Overexpression reduced the death-promoting effects inhibition. Together, these data model in which neurons, part mechanism involving factor–dependent encoding prosurvival factors.