Regulation of JNK by Src During Drosophila Development
0301 basic medicine
JNK Mitogen-Activated Protein Kinases
Metamorphosis, Biological
Genes, Insect
Protein-Tyrosine Kinases
Actins
Enzyme Activation
03 medical and health sciences
Phenotype
Proto-Oncogene Proteins
Phosphoprotein Phosphatases
Animals
Drosophila Proteins
Insect Proteins
Point Mutation
Drosophila
Epidermis
Mitogen-Activated Protein Kinases
Phosphorylation
Phosphotyrosine
Signal Transduction
DOI:
10.1126/science.287.5451.324
Publication Date:
2002-07-27T09:40:21Z
AUTHORS (3)
ABSTRACT
In
Drosophila
, the Jun amino-terminal kinase (JNK) homolog Basket (Bsk) is required for epidermal closure. Mutants for
Src42A
, a
Drosophila
c-
src
protooncogene homolog, are described. Src42A functions in epidermal closure during both embryogenesis and metamorphosis. The severity of the epidermal closure defect in the
Src42A
mutant depended on the amount of Bsk activity, and the amount of Bsk activity depended on the amount of Src42A. Thus, activation of the Bsk pathway is required downstream of Src42A in epidermal closure. This work confirms mammalian studies that demonstrated a physiological link between Src and JNK.
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