Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion

• DOI: 10.1126/science.287.5454.864
• Publication Date: 2002-07-27T09:40:21Z
• Authors: Matthijs Verhage; Ascanio S. Maia; Jaap J. Plomp; Arjen B. Brussaard; Joost H. Heeroma; Hendrika Vermeer; Ruud F. Toonen; Robert E. Hammer; Timo K. van den; Berg; Markus Missler; Hans J. Geuze; Thomas C. Südhof
• Keywords: Neurotransmitter Agents; Synapsin

Brain function requires precisely orchestrated connectivity between neurons. Establishment of these connections is believed to require signals secreted from outgrowing axons, followed by synapse formation selected Deletion a single protein, Munc18-1, in mice leads complete loss neurotransmitter secretion synaptic vesicles throughout development. However, this does not prevent normal brain assembly, including layered structures, fiber pathways, and morphologically defined synapses. After assembly completed, neurons undergo apoptosis, leading widespread neurodegeneration. Thus, depend on secretion, but its maintenance does. Neurotransmitter probably functions validate already established connections.