Salmonella Pathogenicity Island 2-Dependent Evasion of the Phagocyte NADPH Oxidase

• DOI: 10.1126/science.287.5458.1655
• Publication Date: 2002-07-27T09:39:52Z
• Authors: Andrés Vazquez-T...; Yisheng Xu; Jessica Jones-Carson; David W. Holden; Scott M. Lucia; Mary C. Dinauer; Pietro Mastroeni; Ferric C. Fang
• Keywords: Pathogenicity island; Phagocyte

A type III protein secretion system encoded by Salmonella pathogenicity island 2 (SPI2) has been found to be required for virulence and survival within macrophages. Here, SPI2 was shown allow typhimurium avoid NADPH oxidase–dependent killing The ability of SPI2-mutant bacteria survive in macrophages cause lethal infection mice restored abrogation the respiratory burst. Ultrastructural immunofluorescence microscopy demonstrated efficient localization oxidase proximity vacuoles containing but not wild-type bacteria, suggesting that interferes with trafficking oxidase-containing vesicles phagosome.