The Genetic Program of Hematopoietic Stem Cells

• DOI: 10.1126/science.288.5471.1635
• Publication Date: 2002-07-27T09:48:21Z
• Authors: Robert L. Phillips; Robin E. Ernst; Brian Brunk; Natalia Ivanova; Mark A. Mahan; Julia K. Deanehan; Kateri A. Moore; G. Christian Overton; Ihor R. Lemischka
• Keywords: Multipotent Stem Cell; Hematopoietic stem cell

Blood cell production originates from a rare population of multipotent, self-renewing stem cells. A genome-wide gene expression analysis was performed in order to define regulatory pathways cells as well their global genetic program. Subtracted complementary DNA libraries highly purified murine fetal liver were analyzed with bioinformatic and array hybridization strategies. large percentage the several thousand products that have been characterized correspond previously undescribed molecules properties suggestive functions. The complete data, available biological process-oriented database, represent molecular phenotype hematopoietic cell.