PAX8-PPAR γ 1 Fusion in Oncogene Human Thyroid Carcinoma

• DOI: 10.1126/science.289.5483.1357
• Publication Date: 2002-07-27T09:40:21Z
• Authors: Todd G. Kroll; Pasha Sarraf; Lorenza Pecciarini; Chang-Jie Chen; Elisabetta Mueller; Bruce M. Spiegelman; Jonathan A. Fletcher
• Keywords: PAX8; Oncogene Proteins

Chromosomal translocations that encode fusion oncoproteins have been observed consistently in leukemias/lymphomas and sarcomas but not carcinomas, the most common human cancers. Here, we report t(2;3)(q13;p25), a translocation identified subset of thyroid follicular results DNA binding domains transcription factor PAX8 to A F peroxisome proliferator–activated receptor (PPAR) γ1. PAX8-PPARγ1 mRNA protein were detected 5 8 carcinomas 20 adenomas, 10 papillary or multinodular hyperplasias. inhibited thiazolidinedione-induced transactivation by PPARγ1 dominant negative manner. The experiments demonstrate an oncogenic role for PPARγ suggest may be useful diagnosis treatment carcinoma.