β1-6 Branching of Asn-Linked Oligosaccharides Is Directly Associated with Metastasis

• DOI: 10.1126/science.2953071
• Publication Date: 2006-10-05T16:28:58Z
• Authors: James W. Dennis; Suzanne Laferté; Carol Waghorne; Martin L. Breitman; Robert S. Kerbel
• Keywords: Oligosaccharide; Malignant Transformation; Tumor progression

Neoplastic transformation has been associated with a variety of structural changes in cell surface carbohydrates, most notably increased sialylation and β1-6-linked branching complex-type asparagine (Asn)-linked oligosaccharides (that is, -GlcNAcβ1-6Manα1-6Manβ1-). However, little is known about the relevant glycoproteins or how these transformation-related oligosaccharide biosynthesis may affect malignant phenotype. Here it reported that glycoprotein, gp130, major target expression structures directly related to metastatic potential cells. Glycosylation mutants tumor line were selected are deficient both β1-6 GlcNAc transferase V activity situ. Moreover, induction clones nonmetastatic murine mammary carcinoma correlated strongly acquisition potential. The results indicate on gp130 be an important feature progression