Implantation of Bacteroides gingivalis in Nonhuman Primates Initiates Progression of Periodontitis

• DOI: 10.1126/science.3336774
• Publication Date: 2006-10-05T21:21:15Z
• Authors: Stanley C. Holt; Jeffrey Ebersole; Jeffrey Felton; Michael Brunsvold; Kenneth S. Kornman
• Keywords: Bacteroidaceae; Periodontal pathogen

Although periodontitis is a bacterial disease, its multidimensional nature and complexity have made it difficult to definitively prove that specific microorganisms initiate the disease process. The successful implantation of rifampin-resistant strain putative periodontal pathogen Bacteroides gingivalis into microbiota monkeys ( Macaca fascicularis ) resulted in an increase systemic levels antibody microorganism rapid significant bone loss.