Prostaglandins Mediate Inhibition of Gastric Acid Secretion by Somatostatin in the Rat

• DOI: 10.1126/science.6129701
• Publication Date: 2006-10-05T18:37:18Z
• Authors: Moshe Ligumsky; Yoshiaki Goto; Haile Debas; Tadataka Yamada
• Keywords: Male; 0303 health sciences; Gastric Juice; Indomethacin; Stomach; Receptors, Muscarinic; Rats; 3. Good health; 03 medical and health sciences; Cyclic AMP; Prostaglandins; Animals; Carbachol; Receptors, Cholinergic; Somatostatin

Somatostatin, a tetradecapeptide with potent inhibitory actions on gastric acid secretion, potentiated carbamylcholine-induced synthesis and release of prostaglandin E 2 from isolated perfused rat stomachs. The ability of somatostatin to inhibit acid secretion was blocked by indomethacin, an inhibitor of prostaglandin synthesis. These results suggest that prostaglandins mediate gastric acid inhibition by somatostatin in the rat.