Regulation of the Macrophage Content of Neoplasms by Chemoattractants

• DOI: 10.1126/science.6828888
• Publication Date: 2006-10-05T18:37:18Z
• Authors: Barbara Bottazzi; Nadia Polentarutti; Raffaella Acero; Andrea Balsari; Diana Boraschi; Pietro Ghezzi; Mario Salmona; Alberto Mantovani
• Keywords: Male; 0301 basic medicine; Leukemia; Chemotactic Factors; Lymphoma; Macrophages; Sarcoma; Neoplasms, Experimental; Cell Line; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Neoplasms; Animals; Humans; Neoplasm Transplantation

Factor chemotactic for mononuclear phagocytes was found in supernatant fluids of cultured human and mouse tumor cells. In 11 tumors there a correlation observed between activity macrophage content neoplastic tissues. Tumor-derived chemoattractants appear to participate the regulation tumor-associated macrophages.