Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

• DOI: 10.1126/science.8178155
• Publication Date: 2006-10-06T00:01:25Z
• Authors: Kenneth H. Grabstein; June Eisenman; Kurt Shanebeck; Charles Rauch; Subhashini Sriniv...; Victor Fung; Courtney Beers; Jane Richardson; Michael A. Schoen...; Minoo Ahdieh; Lisabeth Johnson; Mark R. Alderson; James D. Watson; Dirk M. Anderson,; Judith G. Giri
• Keywords: clone (Java method); Cloning (programming); Interleukin-4 receptor; Common gamma chain; Interleukin 3

A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new cell growth factor isolated. The cytokine, designated interleukin-15 (IL-15), is produced by wide variety cells tissues shares many biological properties with IL-2. Monoclonal antibodies to beta chain IL-2 receptor inhibited activity IL-15, IL-15 competed for binding IL-2, indicating uses components receptor.