RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8 + T cells

• DOI: 10.1126/science.aad0395
• Publication Date: 2015-09-25T04:05:13Z
• Authors: Nader Yatim; Hélène Jusforgues...; Susana Orozco; Oliver Schulz; Rosa Barreira da ...; Caetano Reis e Sousa; Douglas R. Green; Andrew Oberst; Matthew L. Albert
• Keywords: RIPK1; Priming (agriculture)

Dying to impress the immune system Besides reacting microbes, T cells can also mount responses fragments of dying cells, which they encounter displayed on dendritic cells. Not all activate however, so what differentiates that do? Yatim et al. studied two forms programmed death: apoptosis and necroptosis. Using mouse in culture models inflammatory cell death anti-tumor immunity, found initiated immunity only when signaled through enzyme RIPK1 transcription factor NF-κB. Science , this issue p. 328