Nuclear envelope rupture and repair during cancer cell migration

• DOI: 10.1126/science.aad7297
• Publication Date: 2016-03-25T04:13:45Z
• Authors: Celine M. Denais; Rachel M. Gilbert; Philipp Isermann; Alexandra L. McGr...; Mariska te Lindert; Bettina Weigelin; Patricia M. Davidson; Peter Friedl; Katarina Wolf; Jan Lammerding
• Keywords: ESCRT; Nuclear lamina; Interphase; Inner membrane; Envelope (radar); Nuclear pore

Repairing tears in the nuclear envelope The segregates genomic DNA from cytoplasm and regulates protein trafficking between cytosol nucleus. Maintaining integrity during interphase is considered crucial. However, Raab et al. Denais show that migrating immune cancer cells experience frequent transitory ruptures when they move through tight spaces (see Perspective by Burke). reseals rapidly interphase, assisted components of ESCRT III membrane-remodeling machinery. Science , this issue pp. 359 353 ; see also p. 295