SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

• DOI: 10.1126/science.aat9528
• Publication Date: 2018-11-15T19:08:10Z
• Authors: Nora Kory; Gregory A. Wyant; Gyan Prakash; Jelmi uit de Bos; Francesca Bottanelli; Michael E. Pacold; Sze Ham Chan; Caroline A. Lewis; Tim Wang; Heather R. Keys; Yang Eric Guo; David M. Sabatini
• Keywords: 0301 basic medicine; 570; Biological Transport; Carbon; Mitochondria; Jurkat Cells; 03 medical and health sciences; Sodium-Glucose Transporter 1; Serine; Humans; Genetic Testing; CRISPR-Cas Systems; K562 Cells

Mitochondrial serine transporter identified One-carbon (1C) metabolism is a universal metabolic process that required for purine synthesis and supports the high levels of proliferation in cancer cells. The transport into mitochondria supplies most 1C units needed biosynthesis. Kory et al. used genetic screen to identify long-sought-after mitochondrial transporter. Elucidating key step important our understanding has potential implications treatment. Science , this issue p. eaat9528