A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation

• DOI: 10.1126/science.aau9263
• Publication Date: 2019-07-04T23:05:56Z
• Authors: Yixian Cui; Smriti Parashar; Muhammad Zahoor; Patrick G. Needham; Muriel Mari; Ming Zhu; Shuliang Chen; Hsuan-Chung Ho; Fulvio Reggiori; Hesso Farhan; Jeffrey L. Brodsky; Susan Ferro-Novick
• Keywords: COPII; COPI; Endoplasmic-reticulum-associated protein degradation; Secretory protein

ER-phagy keeps cells healthy In eukaryotic cells, about one-third of all proteins are targeted to the endoplasmic reticulum (ER), which serves as a hub for secretory protein traffic and quality control. Cui et al. studied known Lst1 in yeast SEC24C mammalian that is involved loading cargo into vesicles delivered Golgi complex. response stress caused by starvation or misfolded aggregate-prone proteins, acted promote an additional function—ER-phagy. Together with autophagy receptors on ER, ER domains degradation avert aggregation, thus preserving cellular health. Science , this issue p. 53