Host monitoring of quorum sensing during Pseudomonas aeruginosa infection

• DOI: 10.1126/science.aaw1629
• Publication Date: 2020-02-03T21:48:36Z
• Authors: Pedro Moura-Alves; Andreas Puyskens; Anne Stinn; Marion Klemm; Ute Guhlich-Bornhof; Anca Dorhoi; Jens Furkert; Annika Kreuchwig; Jonas Protze; Laura Lozza; Gang Pei; Philippe Saikali; Carolina Perdomo; Hans J. Mollenkopf; Robert Hurwitz; Frank Kirschhoefer; Gerald Brenner-Weiss; January Weiner; Hartmut Oschkinat; Michael Kolbe; Gerd Krause; Stefan H. E. Kauf...
• Keywords: Cell Signaling

Pseudomonas aeruginosa rapidly adapts to altered conditions by quorum sensing (QS), a communication system that it uses collectively modify its behavior through the production, release, and detection of signaling molecules. QS molecules can also be sensed hosts, although respective receptors pathways are poorly understood. We describe pattern regulation in host aryl hydrocarbon receptor (AhR) is critically dependent on qualitative quantitative P. quorum. bind AhR distinctly modulate activity. This mirrored upon infection with collected from diverse growth stages mutants. propose spying bacterial quorum, acts as major sensor dynamics, capable orchestrating defense according status quo infection.