The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia

• DOI: 10.1126/science.abg0269
• Publication Date: 2021-06-25T00:45:22Z
• Authors: Zengzhang Zheng; Wanyan Deng; Yang Bai; Rui Miao; Shenglin Mei; Zhibin Zhang; Youdong Pan; Yi Wang; Rui Min; Fan Deng; Zeyu Wu; Wu Li; Pengcheng Chen; Tianchi Ma; Xiwen Lou; Judy Lieberman; Xing Liu
• Keywords: Pyroptosis; RIPK1; NLRP1

Cell death limits pathogens During infection, Yersinia inhibition of the protein kinase TAK1 triggers cleavage pore-forming gasdermin D (GSDMD), which leads to a kind inflammatory cell called pyroptosis. In genome-wide screen, Zheng et al. identified lysosome-tethered regulatory supercomplex as being critical driver -induced The activity GTPase Rag and lysosomal tethering Rag-Ragulator were required recruit activate RIPK1 protease caspase-8 cleave GSDMD, causes infection. By contrast, was not for inflammasome-mediated Thus, metabolic signaling on lysosomes can regulate during pathogenic bacterial Science , abg0269, this issue p. eabg0269