Time-restricted feeding mitigates obesity through adipocyte thermogenesis

• DOI: 10.1126/science.abl8007
• Publication Date: 2022-10-20T17:58:30Z
• Authors: Chelsea Hepler; Benjamin J. Weide...; Nathan J. Waldeck; Biliana Marcheva; Jonathan Cedernaes; Anneke K. Thorne; Yumiko Kobayashi; Rino Nozawa; Marsha V. Newman; Peng Gao; Mengle Shao; Kathryn M. Ramsey; Rana K. Gupta; Joseph Bass
• Keywords: Mice, Knockout; 0301 basic medicine; 2. Zero hunger; Time Factors; ARNTL Transcription Factors; Thermogenesis; Creatine; Diet, High-Fat; Circadian Rhythm; DNA-Binding Proteins; Mice; 03 medical and health sciences; Circadian Clocks; Adipocytes; Animals; Obesity; Transcription Factors

Misalignment of feeding rhythms with the light-dark cycle leads to disrupted peripheral circadian clocks and obesity. Conversely, restricting active period mitigates metabolic syndrome through mechanisms that remain unknown. We found genetic enhancement adipocyte thermogenesis ablation zinc finger protein 423 (ZFP423) attenuated obesity caused by consumption a high-fat diet during inactive (light) increasing futile creatine cycling in mice. Circadian control metabolism underlies timing diet-induced thermogenesis, overexpression clock activator brain muscle Arnt-like protein-1 (BMAL1) ameliorated complications These findings uncover rhythmic creatine-mediated as an essential mechanism drives benefits time-restricted feeding.