VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites

• DOI: 10.1126/sciimmunol.aaf6628
• Publication Date: 2016-08-05T00:54:35Z
• Authors: Mohamed Khass; Tessa Blackburn; Peter D. Burrows; Mark R. Walter; Emidio Capriotti; Harry W. Schroeder
• Keywords: Immunoglobulin development, pre-B cell receptor, complementarity-determining region, comparative modeling, protein structure analysis; 0301 basic medicine; 03 medical and health sciences; 3. Good health

The VpreB component of the surrogate light chain serves as an invariant antigen that may affect the repertoire of antibody responses.