Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

• DOI: 10.1126/sciimmunol.aao4013
• Publication Date: 2018-02-08T09:47:07Z
• Authors: Slobodan Culina; Ana Ines Lalanne; Georgia Afonso; Karen Cerosaletti; Sheena Pinto; Guido Sebastiani; Klaudia Kuranda; Laura Nigi; Anne Eugster; Thomas Østerbye; Alicia Maugein; James E. McLaren; Kristin Ladell; Etienne Larger; Jean-Paul Beressi; Anna Lissina; Victor Appay; Howard W. Davidson; Søren Buus; David A. Price; Matthias Kuhn; Ezio Bonifacio; Manuela Battaglia; Sophie Caillat-Zu...; Francesco Dotta; Raphael Scharfmann; Bruno Kyewski; Roberto Mallone; ; Jean-Claude Carel; Nadia Tubiana-Rufi; Laetitia Martinerie; Amélie Poidvin; Evelyne JacqzAigrain; Laurence Corvez; Véronique Berruer; Jean-François Gau...; Baz Baz; Nassima Haddadi; Fabrizio Andreelli; Chloé Amouyal; Sophie Jaqueminet; Olivier Bourron; Eric Dasque; Agnès Hartemann; Amal Lemoine-Yazigi; Danièle Dubois-La...; Florence Travert; Marilyne Feron; Patrice Rolland; Valérie Vignali; Michel Marre; Philippe Chanson; Claire Briet; Pierre-Jean Guill...; Leila Ait-Bachir; Carole Collet; Frédéric Beziaud; Virginie Desforge...; Gwenaelle Petit-A...; Sophie Christin-M...; Bruno Fève; Camille Vatier; Nathalie Bourcigaux; Céline Lautridou; Najiba Lahlou; Prissile Bakouboula; Caroline Elie; Hélène Morel; Jean-Marc Treluyer; Marie-Claude Gagn...; Claire Maillard; Anna Jones
• Keywords: Adult; Male; 0303 health sciences; CD8-Positive T-Lymphocytes; Healthy Volunteers; Cell Line; 3. Good health; Islets of Langerhans; 03 medical and health sciences; Diabetes Mellitus, Type 1; HLA-A2 Antigen; [SDV.IMM]Life Sciences [q-bio]/Immunology; Humans; Female; Child; Pancreas

Islet-reactive CD8 + T cells are common in the periphery, but home to the pancreas preferentially in the context of type 1 diabetes.