Immune recall improves antibody durability and breadth to SARS-CoV-2 variants

• DOI: 10.1126/sciimmunol.abp8328
• Publication Date: 2022-05-12T18:00:50Z
• Authors: Yuezhou Chen; Pei Tong; Noah Whiteman; Ali Sanjari Mogha...; Mehrdad Zarghami; Adam Zuiani; Shaghayegh Habibi; Avneesh Gautam; Keerti; Caihong Bi; Tianshu Xiao; Yongfei Cai; Bing Chen; Donna Neuberg; Duane R. Wesemann
• Keywords: Antibody Repertoire; Original antigenic sin; Memory B cell

Key features of immune memory are greater and faster antigen-specific antibody responses to repeat infection. In the setting immune-evading viral evolution, it is important understand how far recognition stretches across variants when cells recalled action by invasions. It also recall influences longevity secreted responses. We analyzed SARS-CoV-2 variant recognition; dynamics B cells; over time after infection, vaccination, boosting. find that a two-dose vaccination regimen given natural infection generated longitudinal stability induced maximal magnitudes with enhanced breadth Beta, Gamma, Delta Omicron variants. A homologous third messenger RNA vaccine dose in COVID-naïve individuals conferred cross-variant evenness neutralization potency was equal hybrid immunity plus vaccination. Within unvaccinated who recovered from COVID, observed within subgroup more quickly COVID harbored significantly cross-reactive endemic coronaviruses early These clones map conserved S2 region spike higher somatic hypermutation levels target affinity. conclude antigen challenge histories humans influence not only speed magnitude but functional repertoire composition longevity.