Immunization with germ line–targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques

• DOI: 10.1126/sciimmunol.adm7097
• Publication Date: 2024-08-30T17:58:52Z
• Authors: Ashley N. Nelson; Xiaoying Shen; Sravani Vekatayogi; Shiyu Zhang; Gabriel Ozorowski; Maria Dennis; Leigh M. Sewall; Emma Milligan; Dominique Davis; Kaitlyn A. Cross; Yue Chen; Jelle van Schooten; Joshua Eudailey; John Isaac; Saad Memon; Carolyn Weinbaum; Hongmei Gao; Sherry Stanfield-...; Alliyah Byrd; Suni Chutkan; Stella Berendam; Kenneth Cronin; Anila Yasmeen; S. Alam; Celia C. LaBranche; Kenneth Rogers; Lisa Shirreff; Albert Cupo; Ronald Derking; Francois Villinger; Per Johan Klasse; Guido Ferrari; Wilton B. Williams; Michael G. Hudgens; Andrew B. Ward; David C. Montefiori; Koen K. A. Van Ro...; Kevin Wiehe; John P. Moore; Rogier W. Sanders; Kristina De Paris; Sallie R. Permar
• Keywords: AIDS Vaccines; 0301 basic medicine; env Gene Products, Human Immunodeficiency Virus; HIV Infections; HIV Antibodies; Macaca mulatta; Antibodies, Neutralizing; 03 medical and health sciences; Germ Cells; HIV-1; Animals; Humans; Immunization; Broadly Neutralizing Antibodies

Adolescents are a growing population of people living with HIV. The period between weaning and sexual debut presents low-risk window for HIV acquisition, making early childhood an ideal time implementing immunization regimen. Because the elicitation broadly neutralizing antibodies (bnAbs) is critical effective vaccine, our goal was to assess ability bnAb B cell lineage-designed envelope SOSIP (protein stabilized by disulfide bond gp120-gp41-named "SOS"-and isoleucine-to-proline point mutation-named "IP"-at residue 559) induce precursor CD4 binding site (CD4bs)-targeting bnAbs in life. Infant rhesus macaques received either BG505 SOSIP, based on infant transmitted/founder virus, or CD4bs germ line-targeting GT1.1 (