Polycomb Group Proteins as Epigenetic Mediators of Neuroprotection in Ischemic Tolerance

• DOI: 10.1126/scisignal.2000502
• Publication Date: 2010-03-02T21:44:22Z
• Authors: Martha Stapels; Chelsea Piper; Tao Yang; Minghua Li; Cheri Stowell; Zhi-gang Xiong; Julie Saugstad; Roger P. Simon; Scott Geromanos; James Langridge; Jing-quan Lan; An Zhou
• Keywords: Male; Polycomb Repressive Complex 1; Proteomics; 0303 health sciences; Base Sequence; Nuclear Proteins; Polycomb-Group Proteins; In Vitro Techniques; Brain Ischemia; Epigenesis, Genetic; Mice, Inbred C57BL; Repressor Proteins; Kv1.5 Potassium Channel; Mice; 03 medical and health sciences; Neuroprotective Agents; Proto-Oncogene Proteins; Shaker Superfamily of Potassium Channels; Animals; RNA, Small Interfering; Promoter Regions, Genetic; Signal Transduction

Polycomb group proteins protect neurons from injury through a mechanism involving decreased potassium channel function.