Self-Induced Patched Receptor Down-Regulation Modulates Cell Sensitivity to the Hedgehog Morphogen Gradient

Morphogen Patched Smoothened
DOI: 10.1126/scisignal.2001059 Publication Date: 2010-08-24T21:36:47Z
ABSTRACT
A self-regulating receptor allows cells to maintain the appropriate balance of ligand-bound and unbound receptors.
SUPPLEMENTAL MATERIAL
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