IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors

• DOI: 10.1126/scisignal.2003184
• Publication Date: 2012-12-18T20:38:36Z
• Authors: Valentina Evdokimova; Cristina E. Tognon; Tania Benatar; Wenyi Yang; Konstantin Krutikov; Michael Pollak; Poul H. B. Sorensen; Arun Seth
• Keywords: Mice, Knockout; 0301 basic medicine; Cell Survival; Apoptosis; Breast Neoplasms; Cell Cycle Proteins; Mice, SCID; Phosphoproteins; Neoplasm Proteins; Insulin-Like Growth Factor Binding Proteins; Mice; 03 medical and health sciences; Insulin-Like Growth Factor II; Mice, Inbred NOD; Cell Line, Tumor; Animals; Humans; Female; Eukaryotic Initiation Factors; Insulin-Like Growth Factor I; Carrier Proteins; Adaptor Proteins, Signal Transducing

By inactivating the insulin-like growth factor receptor, IGFBP7 suppresses and promotes cell death.