Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation

• DOI: 10.1126/scisignal.2005769
• Publication Date: 2015-04-28T18:32:57Z
• Authors: Kristina B. Emdal; Anna-Kathrine Ped...; Dorte B. Bekker-J...; Kalliopi P. Tsafou; Heiko Horn; Sven Lindner; Johannes H. Schulte; Angelika Eggert; Lars J. Jensen; Chiara Francavilla; Jesper V. Olsen
• Keywords: 0301 basic medicine; MAP Kinase Signaling System; Medizin; Cell Differentiation; Neuroblastoma; 03 medical and health sciences; Cell Line, Tumor; Nerve Growth Factor; Neurites; Humans; Proto-Oncogene Proteins c-cbl; Receptor, trkA; Adaptor Proteins, Signal Transducing

Proteomic analysis of neurotrophin signaling identifies an inhibitory E3 ubiquitin ligase.