Frontrunners of T cell activation: Initial, localized Ca 2+ signals mediated by NAADP and the type 1 ryanodine receptor

• DOI: 10.1126/scisignal.aab0863
• Publication Date: 2015-10-14T00:46:05Z
• Authors: Insa M. A. Wolf; Björn-Philipp Die...; Ellen Gattkowski; Frederik Czarniak; Jan Kempski; René Werner; Daniel Schetelig; Hans-Willi Mittrü...; Valéa Schumacher; Manuel von Osten; Dimitri Lodygin; Alexander Flügel; Ralf Fliegert; Andreas H. Guse
• Keywords: Jurkat cells; Second messenger system; TRPM2; Calcium Signaling; NFAT; Immunological synapse

High-resolution imaging of live T cells characterizes the early Ca 2+ signals required for cell activation.