Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

• DOI: 10.1126/scisignal.aai7696
• Publication Date: 2017-04-04T21:02:28Z
• Authors: Alex M. Dickens; Luis B. Tovar-y-Romo; Seung-Wan Yoo; Amanda L. Trout; Mihyun Bae; Marlene Kanmogne; Bezawit Megra; Dionna W. Williams; Kennith W. Witwer; Mar Gacias; Nino Tabatadze; Robert N. Cole; Patrizia Casaccia; Joan W. Berman; Daniel C. Anthony; Norman J. Haughey
• Keywords: Extracellular Vesicles; Inflammatory response

Vesicles shed from astrocytes after brain trauma trigger hepatic cytokine release to mobilize the peripheral immune response.