Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β

• DOI: 10.1126/scisignal.aao3469
• Publication Date: 2019-01-16T00:26:22Z
• Authors: Monika Lodyga; Elizabeth Cambridge; Henna M. Karvonen; Pardis Pakshir; Brian Wu; Stellar Boo; Melanie Kiebalo; Riitta Kaarteenaho; Michael Glogauer; Mohit Kapoor; Kjetil Ask; Boris Hinz
• Keywords: Male; 0301 basic medicine; Macrophages; Fibroblasts; Cadherins; Fibrosis; Coculture Techniques; Mice, Inbred C57BL; Microscopy, Electron; 03 medical and health sciences; Transforming Growth Factor beta; Cell Adhesion; Animals; Humans; RNA Interference; Myofibroblasts; Cells, Cultured; Protein Binding; Signal Transduction

Adhesion with macrophages promotes the activation of fibroblasts into myofibroblasts and creates a self-sustaining profibrotic niche.