Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

• DOI: 10.1126/scisignal.aap7336
• Publication Date: 2019-09-10T23:15:12Z
• Authors: Laura F. Bennett; Chang Liao; Michael D. Quickel; Beng San Yeoh; Matam Vijay-Kumar; Pamela Hankey-Giblin; K. Sandeep Prabhu; Robert F. Paulson
• Keywords: Erythroid Precursor Cells; Inflammation; Mice, Knockout; 0301 basic medicine; Erythrocytes; Growth Differentiation Factor 15; Macrophages; Bone Morphogenetic Protein 4; Heme; 3. Good health; DNA-Binding Proteins; Mice, Inbred C57BL; 03 medical and health sciences; Phagocytosis; Stress, Physiological; Animals; Erythropoiesis; Spleen; Signal Transduction

Erythrophagocytosis and the production of proinflammatory cytokines promote stress erythropoiesis during inflammation.