The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing α-synuclein

• DOI: 10.1126/scisignal.aat4285
• Publication Date: 2018-12-12T00:25:13Z
• Authors: TaeHee Kim; Suresh L. Mehta; Kahlilia C. Morri...; Anil K. Chokkalla; Bharath Chelluboina; Mary Lopez; Ruth Sullivan; Hung Tae Kim; Thomas D. Cook; Joo Yong Kim; HwuiWon Kim; Chanul Kim; Raghu Vemuganti
• Keywords: Male; Mice, Knockout; Apoptosis; Mitochondrial Dynamics; Brain Ischemia; Rats; Mice, Inbred C57BL; Motor Skills Disorders; Stroke; MicroRNAs; Oxidative Stress; 03 medical and health sciences; 0302 clinical medicine; Rats, Inbred SHR; Reperfusion Injury; Autophagy; alpha-Synuclein; Animals; Administration, Intravenous; Female

Rapid intervention with an miR-7 mimic may protect the brain in patients who have had a stroke.