Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

• DOI: 10.1126/scisignal.aat9900
• Publication Date: 2019-01-09T00:25:15Z
• Authors: Souvarish Sarkar; Dharmin Rokad; Emir Malovic; Jie Luo; Dilshan S. Harisc...; Huajun Jin; Vellareddy Ananth...; Xuemei Huang; Mechelle Lewis; Arthi Kanthasamy; Anumantha G. Kant...
• Keywords: Male; Manganese; 0303 health sciences; Inflammasomes; Caspase 1; Interleukin-1beta; Exosomes; CARD Signaling Adaptor Proteins; Mice, Inbred C57BL; 03 medical and health sciences; NLR Family, Pyrin Domain-Containing 3 Protein; Animals; Welding; Microglia; Cells, Cultured; Signal Transduction

Exosomes containing the adaptor ASC spread NLRP3 inflammasome activation between cells after manganese exposure.