Immunometabolism regulates TCR recycling and iNKT cell functions

• DOI: 10.1126/scisignal.aau1788
• Publication Date: 2019-02-27T00:25:12Z
• Authors: Sicheng Fu; Shasha Zhu; Chenxi Tian; Shiyu Bai; Jiqian Zhang; Chonglun Zhan; Di Xie; Lu Wang; Zonghong Li; Jie Li; Huimin Zhang; Rongbin Zhou; Zhigang Tian; Tao Xu; Li Bai
• Keywords: CD4-Positive T-Lymphocytes; 0301 basic medicine; Receptors, Antigen, T-Cell; Mice, Transgenic; Mechanistic Target of Rapamycin Complex 2; Lymphocyte Activation; Mitochondria; 12. Responsible consumption; Mice, Inbred C57BL; Interferon-gamma; 03 medical and health sciences; Hexokinase; Animals; Natural Killer T-Cells; Glycolysis; Cells, Cultured; Signal Transduction

Glycolysis augments T cell receptor recycling to promote downstream signaling and interferon-γ responses in iNKT cells.