Desynchronization of the molecular clock contributes to the heterogeneity of the inflammatory response

• DOI: 10.1126/scisignal.aau1851
• Publication Date: 2019-03-06T00:17:12Z
• Authors: Nancy C. Allen; Naomi H. Philip; Lucy Hui; Xu Zhou; Ruth A. Franklin; Yong Kong; Ruslan Medzhitov
• Keywords: DNA-Binding Proteins; Lipopolysaccharides; Mice; 0303 health sciences; 03 medical and health sciences; Basic-Leucine Zipper Transcription Factors; Biological Clocks; Interleukin-12 Subunit p40; Macrophages; Animals; Mice, Transgenic; Transcription Factors

Differences in the phase of the circadian clock contribute to heterogeneity in the inflammatory response of macrophages.