A G protein–biased S1P 1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers

• DOI: 10.1126/scisignal.aax8050
• Publication Date: 2020-06-02T23:15:20Z
• Authors: Bruno Poirier; Veronique Briand; Dieter Kadereit; Matthias Schäfer; Paulus Wohlfart; Marie-Claire Phil...; Dominique Caillaud; Laurent Gouraud; Patrick Grailhe; Jean-Pierre Bidouard; Marc Trellu; Anthony J. Muslin; Philip Janiak; Ashfaq A. Parkar
• Keywords: Sphingosine-1-phosphate receptor; Endothelial Dysfunction; Homeostasis

A biased S1P 1 agonist that preserves endothelial function without causing lymphopenia is identified.