STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis

• DOI: 10.1126/scisignal.abj8393
• Publication Date: 2021-12-07T18:55:23Z
• Authors: Ying Shen; Xiaohong Wang; Yi Liu; Mahak Singhal; Can Gürkaşlar; Aida Freire Valls; Yi Lei; Wenjie Hu; Géza Schermann; Heike Adler; Fa-Xing Yu; Tamás Fischer; Yi Zhu; Hellmut G. Augustin; Thomas Schmidt; Carmen Ruiz de Al...
• Keywords: STAT3 Transcription Factor; 0303 health sciences; 03 medical and health sciences; 572; Neoplasms; Endothelial Cells; Humans; YAP-Signaling Proteins; Phosphoproteins; Adaptor Proteins, Signal Transducing; Signal Transduction

Nuclear cotranslocation with STAT3 enables YAP/TAZ to activate genes involved in tumor vascularization.