In Situ Regulation of DC Subsets and T Cells Mediates Tumor Regression in Mice

• DOI: 10.1126/scitranslmed.3000359
• Publication Date: 2009-11-26T02:34:20Z
• Authors: Omar A. Ali; Dwaine Emerich; Glenn Dranoff; David J. Mooney
• Keywords: 0301 basic medicine; 610; Granulocyte-Macrophage Colony-Stimulating Factor; Dendritic Cells; Neoplasms, Experimental; Cancer Vaccines; Interleukin-12; 3. Good health; Mice; 03 medical and health sciences; Animals; CpG Islands; Interferons; T-Lymphocytes, Cytotoxic

An implanted copolymer matrix that incorporates inflammatory cytokines, an immune danger signal, and tumor antigens elicits an immune response network that can eradicate established tumors in mice.