Differential Inhibitor Sensitivity of Anaplastic Lymphoma Kinase Variants Found in Neuroblastoma

• DOI: 10.1126/scitranslmed.3002950
• Publication Date: 2011-11-09T19:49:12Z
• Authors: Scott C. Bresler; Andrew C. Wood; Elizabeth A. Haglund; Joshua Courtright; Lili T. Belcastro; Jefferson S. Pleg...; Kristina Cole; Yana Toporovskaya; Huaqing Zhao; Erica L. Carpenter; James G. Christensen; John M. Maris; Mark A. Lemmon; Yaël P. Mossé
• Keywords: ALK inhibitor; Anaplastic large-cell lymphoma

Neuroblastoma sensitivity to crizotinib depends on the ATP-binding affinity of ALK variants, suggesting that higher doses may overcome resistance.