Paracrine Signaling Through MYCN Enhances Tumor-Vascular Interactions in Neuroblastoma

• DOI: 10.1126/scitranslmed.3002977
• Publication Date: 2012-01-05T19:41:12Z
• Authors: Yvan H. Chanthery; W. Clay Gustafson; Melissa Itsara; Anders Persson; Christopher S. Ha...; Matt Grimmer; Elise Charron; Slava Yakovenko; Grace Kim; Katherine K. Matthay; William A. Weiss
• Keywords: Oncogene Proteins; N-Myc Proto-Oncogene Protein; Neovascularization, Pathologic; Brain Neoplasms; Imidazoles; Nuclear Proteins; Angiogenesis Inhibitors; Mice, Transgenic; Proto-Oncogene Mas; 3. Good health; Gene Expression Regulation, Neoplastic; Mice; Neuroblastoma; Phosphatidylinositol 3-Kinases; Cell Line, Tumor; Proto-Oncogene Proteins; Paracrine Communication; Human Umbilical Vein Endothelial Cells; Animals; Humans; Neoplasm Transplantation

PI3K/mTOR inhibitors inhibit angiogenesis by blocking MYCN-dependent paracrine signaling between tumor and endothelial cells.